Click to search for your profile
Click to search for condition or expert
Click to open main menu
Save Condition
Bookmark
Share
Share
Condition
Clinical Trials for
Paroxysmal Nocturnal Hemoglobinuria
Overview
Find a Doctor
Latest Advances
Clinical Trials
Clinical Trials
Search for trials
Filter
Clinical Trial
Status:
Not yet recruiting
Phase:
Phase 3
Intervention Type:
Drug
Participants:
167
Start Date:
June 3, 2021
An Open Label, Multicenter Roll-over Extension Program (REP) to Characterize the Long-term Safety and Tolerability of Iptacopan (LNP023) in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Completed PNH Phase 2 and Phase3 Studies With Iptacopan
Clinical Trial
Status:
Not yet recruiting
Phase:
Phase 3
Intervention Type:
Drug
Participants:
50
Start Date:
March 10, 2021
A Phase III, Multicenter, Single Arm Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibition
Search for trials
Clinical Trial
Status:
Recruiting
Phase:
Phase 3
Intervention Type:
Drug
Participants:
91
Start Date:
January 25, 2021
A Randomized, Multicenter, Active-comparator Controlled, Open-label Trial to Evaluate Efficacy and Safety of Oral, Twice Daily LNP023 in Adult Patients With PNH and Residual Anemia, Despite Treatment With an Intravenous Anti-C5 Antibody.
Clinical Trial
Status:
Not yet recruiting
Phase:
Phase 4
Intervention Type:
Biological
Participants:
20
Start Date:
January 2021
Phase 4, Single-Arm Study of Ravulizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Currently Treated With High-Dose Eculizumab
Clinical Trial
Status:
Enrolling by invitation
Phase:
Phase 2
Intervention Type:
Drug
Participants:
200
Start Date:
December 18, 2020
A Phase 2, Open-Label Study to Evaluate the Long-term Safety of Oral BCX9930 in Subjects With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Clinical Trial
Status:
Recruiting
Phase:
Phase 3
Intervention Type:
Drug
Participants:
84
Start Date:
December 16, 2020
A Phase 3 Study of Danicopan (ALXN2040) as Add-on Therapy to a C5 Inhibitor (Eculizumab or Ravulizumab) in Patients With Paroxysmal Nocturnal Hemoglobinuria Who Have Clinically Evident Extravascular Hemolysis (EVH)
Clinical Trial
Status:
Recruiting
Phase:
Phase 3
Intervention Type:
Drug
Participants:
200
Start Date:
October 8, 2020
A Phase III, Randomized, Open-Label, Active-Controlled, Multicenter Study Evaluating The Efficacy And Safety Of Crovalimab Versus Eculizumab In Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors.
Clinical Trial
Status:
Not yet recruiting
Intervention Type:
Other
Participants:
60
Start Date:
October 2020
The Pharmacokinetics and Pharmacodynamics of Eculizumab in Patients With Paroxysmal Nocturnal Hemoglobinuria
Clinical Trial
Status:
Recruiting
Phase:
Phase 3
Intervention Type:
Drug
Participants:
250
Start Date:
September 30, 2020
A Phase III, Randomized, Open-Label, Active-Controlled, Multicenter Study Evaluating The Efficacy And Safety Of Crovalimab Versus Eculizumab In Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors.
Clinical Trial
Status:
Recruiting
Phase:
Phase 1/Phase 2
Intervention Type:
Drug
Participants:
148
Start Date:
March 3, 2020
A Phase 1 Dose-ranging Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of BCX9930 in Healthy Subjects and in Subjects With Paroxysmal Nocturnal Hemoglobinuria
Clinical Trial
Status:
Recruiting
Phase:
Phase 2
Intervention Type:
Drug
Participants:
26
Start Date:
December 16, 2019
A Phase 2 Open-Label Proof of Concept Study to Assess the Efficacy, Safety, and Pharmacokinetics of the Oral Factor D (FD) Inhibitor ACH-0145228 in Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients as Monotherapy and With an Approved C5 Inhibitor as Background Therapy
Clinical Trial
Status:
Enrolling by invitation
Phase:
Phase 3
Intervention Type:
Drug
Participants:
147
Start Date:
December 3, 2019
An Open-label Extension Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of REGN3918 in Patients With Paroxysmal Nocturnal Hemoglobinuria
Showing 1-12 of 42
Next