Plaque Psoriasis Clinical Trials

• Participants with moderate-to-severe plaque psoriasis:

‣ Deemed by the Investigator to be a candidate for phototherapy or systemic treatment for psoriasis, including ustekinumab;

⁃ Have at least 1 of the following cardiovascular risk factors:

• Current cigarette smoker

• Diagnosis of hypertension

• Diagnosis of hyperlipidemia

• Diabetes mellitus type 1 or 2

• History of one or more of the following cardiovascular events: Coronary intervention (PCI) or coronary artery bypass grafting (CABG), myocardial infarction (heart attack), cardiac arrest, hospitalization for unstable angina, acute coronary syndrome, stroke, or transient ischemic attack

• Obesity

• Family history of premature coronary heart disease or sudden death in a first-degree male relative younger than 55 years of age or in a first-degree female relative younger than 65 years of age.