Learn About Poland Syndrome

What is the definition of Poland Syndrome?

Poland syndrome is a disorder in which affected individuals are born with missing or underdeveloped muscles on one side of the body, resulting in abnormalities that can affect the chest, shoulder, arm, and hand. The extent and severity of the abnormalities vary among affected individuals.

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What are the causes of Poland Syndrome?

The cause of Poland syndrome is unknown. Researchers have suggested that it may result from a disruption of blood flow during development before birth. This disruption is thought to occur at about the sixth week of embryonic development and affect blood vessels that will become the subclavian and vertebral arteries on each side of the body. The arteries normally supply blood to embryonic tissues that give rise to the chest wall and hand on their respective sides. Variations in the site and extent of the disruption may explain the range of signs and symptoms that occur in Poland syndrome. Abnormality of an embryonic structure called the apical ectodermal ridge, which helps direct early limb development, may also be involved in this disorder.

How prevalent is Poland Syndrome?

Poland syndrome has been estimated to occur in 1 in 20,000 newborns. For unknown reasons, this disorder occurs more than twice as often in males than in females. Poland syndrome may be underdiagnosed because mild cases without hand involvement may never come to medical attention.

Is Poland Syndrome an inherited disorder?

Most cases of Poland syndrome are sporadic, which means they are not inherited and occur in people with no history of the disorder in their families. Rarely, this condition is passed through generations in families. In these families the condition appears to be inherited in an autosomal dominant pattern, which means one copy of an altered gene in each cell is sufficient to cause the disorder, although no associated genes have been found.

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Published Date: April 01, 2016Published By: National Institutes of Health

What are the Latest Advances for Poland Syndrome?
Poland's syndrome concomitant with congenital proximal and distal radioulnar synostosis: A rare case report.
Summary: Poland's syndrome concomitant with congenital proximal and distal radioulnar synostosis: A rare case report.
Robotic-assisted latissimus dorsi muscle flap for autologous chest reconstruction in poland syndrome.
Summary: Robotic-assisted latissimus dorsi muscle flap for autologous chest reconstruction in poland syndrome.
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Breast Reconstruction in Poland Syndrome Patients with Latissimus Dorsi Myo Flap and Implant: An Efficient Endoscopic Approach Using Single Transverse Axillary Incision.
Summary: Breast Reconstruction in Poland Syndrome Patients with Latissimus Dorsi Myo Flap and Implant: An Efficient Endoscopic Approach Using Single Transverse Axillary Incision.