Whole Genetic Approach in Early Genetic Identification of Obesity (WEGIO)
TITLE: Whole genetic approach in Early Genetic Identification of Obesity (WEGIO) DESIGN: Multicenter epidemiological study STUDY POPULATION: Participants at risk for a syndromic or a monogenic genetic obesity, incl. participants clinically diagnosed with Bardet-Biedl-Syndrome (BBS) NUMBER OF PARTICIPANTS: 1000 for initial genetic sequencing and app. 40 for the follow-up documentation COORDINATING INVESTIGATOR: Prof. Dr. Arndt Rolfs
• Informed consent is obtained from the participant/parent/legal guardian
• The participant is 2 years of age or older
⁃ For a participant between 2 and 18 years of age:
• The participant has and had a body weight more than 97th percentile before the age of 6
• The participant has one or more of the following symptoms:
⁃ rod/cone dystrophy, renal abnormalities, ataxia, syndactyly, polydactyly, brachydactyly, hyperphagia, cognitive impairment, speech delay, hypogonadism
⁃ For a participant who is 18 years of age or older:
• The participant has BMI ≥ 30 kg/m2
• The participant had a body weight more than 97th percentile before the age of 6 years
• The participant has rod/cone dystrophy
• The participant is 2 or more years of age, is clinically diagnosed with Bardet-Biedl-Syndrome (BBS) or is a sibling of an individual diagnosed with BBS via the WEGIO study