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          Last Updated: 04/22/2023

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            Phase I/II Trial of Everolimus in Combination With Lonafarnib in Progeria

            Who is this study for: Children and adults with progeria
            Enrollment Status: Enrolling by invitation
            Publish Date: February 27, 2023
            Intervention Type: Drug
            Study Drugs: Everolimuslonafarnib
            Study Phase: Phase 1/Phase 2
            Distance: 404.2 mi

            Summary: This is a phase I/II dose-escalation trial of everolimus in combination with lonafarnib in Hutchinson-Gilford Progeria Syndrome (HGPS) and progeroid laminopathies (henceforth progeria). The study will be conducted at a single clinical site utilizing the Clinical and Translational Study Unit (CTSU) at Boston Children's Hospital. Lonafarnib will be administered at doses previously established in the...

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            Last Updated: 04/22/2023