Learn About Progressive Familial Intrahepatic Cholestasis Type 3

What is the definition of Progressive Familial Intrahepatic Cholestasis Type 3?
Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare condition that affects the liver. People with this condition generally develop signs and symptoms during late infancy or early childhood, which may include severe itching, jaundice, failure to thrive, portal hypertension (high blood pressure in the vein that provides blood to the liver) and hepatosplenomegaly (enlarged liver and spleen). The condition may progress to liver failure during childhood or adulthood. PFIC3 is caused by change in the ABCB4 gene and is inherited in an autosomal recessive manner.
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What are the alternative names for Progressive Familial Intrahepatic Cholestasis Type 3?
  • Progressive familial intrahepatic cholestasis type 3
  • MDR3 deficiency
  • PFIC3
  • Progressive familial intrahepatic cholestasis with elevated serum gamma-glutamyltransferase
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Published Date: May 06, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Progressive Familial Intrahepatic Cholestasis Type 3?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.