Biomarkers in Neurodegenerative Diseases

Status: Recruiting
Location: See location...
Study Type: Observational [Patient Registry]

With the increase in life expectancy of our population due to advancement of medical diagnosis and treatments, the incidence of age dependent neurodegenerative diseases increased, including Alzheimer's disease (AD), parkinsonian syndromes (PS), small vessel disease (SVD) and motor neuron disease (MND). In spite of the progress of knowing the pathogenesis of various neurodegenerative diseases at molecular and genetic level, they are still very incompletely understood and often cause diagnostic and therapeutic challenges to physicians. Due to the overlapping presentation and similar brain pathology, especially in the early stage of the diseases, it is difficult to differentiate idiopathic Parkinson's disease (iPD) from atypical parkinsonian syndromes, such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Similarly, distinguishing AD from other dementia syndromes including frontotemporal dementia (FTD), dementia with Lewy Bodies (DLB), corticobasal degeneration (CBD) and vascular dementia can be difficult. It is necessary to develop accurate and comprehensive diagnostic tests to properly prognosticate the diseases, start treatments in early stage of the diseases and maximize the accuracy of drug trials for more effective preventive and therapeutic measures for these neurodegenerative diseases. Therefore, the registry aims to generate a large database of cognitive, behavioral, lifestyle and psychological information of the subjects who suffered from neurodegenerative diseases, as well as to examine the genetic basis of neurodegenerative diseases to help decode the pathogenic mechanisms of the diseases. The registry may provide important information to understand symptom development of the neurodegenerative diseases, in which may help physicians to diagnose the diseases more accurately and provide better treatment plans.

Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: Accepts Healthy Volunteers

• Age should be between 18-80 years old.

Other Locations
Hong Kong Special Administrative Region
Chinese University of Hong Kong
Hong Kong
Contact Information
Elyia Han, Bachelor
+852 2697 5027
Pauline Kwan, Master
+852 2635 2160
Time Frame
Start Date: October 9, 2019
Estimated Completion Date: August 2024
Target number of participants: 1400
Early idiopathic Parkinson's Disease
200 patients with iPD based on Movement Disorder Society clinical diagnostic criteria for Parkinson's disease with disease onset less than 5 years
Non-early idiopathic Parkinson's Disease
200 patients with iPD based on Movement Disorder Society clinical diagnostic criteria for Parkinson's disease with disease onset more than 5 years
Multiple System Atrophy
100 patients with Multiple System Atrophy based on Second consensus statement on the diagnosis of MSA
Progressive Supranuclear Palsy
100 patients with Progressive Supranuclear Palsy based on Clinical research criteria for diagnosis of PSP
Alzheimer's Disease
100 patients with Alzheimer's Disease by Diagnostic and Statistical Manual of Mental disorder, Fifth edition (DSM-5) criteria
Motor Neuron Disease
200 patients with Motor Neuron Diseases by revised El Escorial criteria or Awaji ALS criteria
Small Vessel Disease
200 patients with cerebral Small Vessel Diseases
Frontotemporal Dementia
100 patients with Frontotemporal Dementia by International consensus criteria for behavioral variant FTD (FTDC) or Primary Progressive Aphasia by Gorno-Tempini
Healthy Control
200 age and sex matched healthy controls
Leads: Vincent Mok

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