Schizophrenia Clinical Trials

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Immunoinflammatory State Detection and Multimodal Brain Imaging and Electrophysiologic Changes in Schizophrenia

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Schizophrenia is a severe mental illness that seriously affects the health and functioning of patients. Previous studies have found immunoinflammatory abnormalities in the blood, cerebrospinal fluid, central nervous system, and neuroimaging of people with schizophrenia, along with therapeutic effects of anti-inflammatory drugs on schizophrenia. These evidences suggest a close relationship between schizophrenia and immunity and inflammation. Therefore, we consider that the state of immune inflammation is a potential subtype classification basis for schizophrenia, and hypothesize that immune classification based on peripheral-central multidimensional data is related to patient's response to medication and cognition.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: t
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• Clinical diagnosis that meets ICD-11 criteria for schizophrenia.

• Confirmation of the diagnosis of schizophrenia using the SCID-5-RV.

Locations
Other Locations
China
Department of Psychiatry, the Second Xiangya Hospital of Central South University
RECRUITING
Changsha
Contact Information
Primary
Renrong Wu, M.D., Ph.D.
wurenrong2013@163.com
+86 15874179855
Time Frame
Start Date: 2025-01-10
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 200
Treatments
Individuals with schizophrenia
Inclusion Criteria:~1. Clinical diagnosis that meets ICD-11 criteria for schizophrenia.~2. Confirmation of the diagnosis of schizophrenia using the SCID-5-RV.~Exclusion criteria:~1. Clinical diagnosis or SCID-5-RV assessment confirming neurodevelopmental disorders, bipolar and related disorders, substance use disorders (excluding alcohol and tobacco).~2. Presence of severe or acute physical illnesses, including traumatic brain injury, intracranial space-occupying or infectious diseases, acute cardiovascular diseases, acute respiratory system diseases, acute hematological disorders, autoimmune disease, etc.~3. Presence of clearly defined genetic diseases, including tuberous sclerosis, multiple sclerosis, Kleefstra syndrome, 22q11.2 deletion syndrome, Prader-Willi syndrome, Klinefelter syndrome (47, XXY), etc.
Healthy volunteers
1. No diagnosis of any mental disorder.~2. First degree relatives without mental disorders.~Exclusion criteria are the same as for the schizophrenia patient group.
Related Therapeutic Areas
Sponsors
Leads: Central South University

This content was sourced from clinicaltrials.gov