Recurrent Scleritis and Immunoglobulin A Nephropathy - A Case Series and Literature Review of an Unusual Association.
Summary: This case series describes patients with recurrent scleritis and immunoglobulin A nephropathy treated with prednisone and telmisartan.
Conclusion: Patients with recurrent scleritis and immunoglobulin A nephropathy were successfully treated with prednisone and telmisartan.
Immunoglobulin A (IgA) nephropathy is usually restricted to the kidneys in most cases, but associations with other immune and inflammatory diseases exist. Scleritis, however, is an unusual association. We present an observational case series of two patients who initially presented with recurrent episodes of scleritis. A thorough evaluation for recurrent scleritis did not reveal any secondary cause per se. They were further evaluated extensively for incidental proteinuria and microscopic hematuria. Renal function was normal. Renal biopsy was performed which revealed IgA nephropathy in both the patients. They were given oral prednisolone and telmisartan for six months and followed for nine and six months, respectively, after steroids were discontinued. Proteinuria remitted, renal function remained normal, and there were no further episodes of scleritis in these patients.