A Case-control Study of the Gastrointestinal Response to a Liquid Test Meal in Chronic Intestinal Pseudo-obstruction, Using Magnetic Resonance Imaging

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic Test
Study Type: Observational
SUMMARY

This study will explore the potential for a standardized MRI scan after a liquid meal to be used in diagnosis of the rare but debilitating chronic intestinal pseudo-obstruction (CIPO).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 16
Healthy Volunteers: No
View:

• Ability to give informed consent

• Sufficient level of English language to understand study information and respond to symptom questionnaires

• CASES: a clinical diagnosis of primary or secondary Chronic Intestinal Pseudo-Obstruction, excluding adhesional obstruction. PICs will be asked to send clinical documentation that the diagnosis has been confirmed on crosssectional imaging.

• CONTROLS: a Chronic constipation disorder diagnosed according to Rome IV criteria for functional constipation, constipation-predominant irritable bowel syndrome or opioid-induced constipation (diagnostic criteria as listed in Lacy et al 2016)

Locations
Other Locations
United Kingdom
University of Nottingham
Recruiting
Nottingham
Contact Information
Primary
Giles Major, PhD
giles.major@nottingham.ac.uk
+44 115 8231035
Backup
Neele Dellschaft, PhD
neele.dellschaft@nottingham.ac.uk
+44 115 8467774
Time Frame
Start Date: January 17, 2020
Estimated Completion Date: December 30, 2022
Participants
Target number of participants: 16
Treatments
CIPO (case)
MRI scan of gastrointestinal content and activity
Chronic constipation (control)
MRI scan of gastrointestinal content and activity
Sponsors
Collaborators: Northern Care Alliance NHS Foundation Trust, Barts & The London NHS Trust, Pseudo-Obstruction Research Trust, Oxford University Hospitals NHS Trust, Manchester University NHS Foundation Trust, Cambridge University Hospitals NHS Foundation Trust, London North West Healthcare NHS Trust
Leads: University of Nottingham

This content was sourced from clinicaltrials.gov

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