Sarcopenia and Short Bowel Syndrome: the Microbiota-gut-muscle Axis

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Sarcopenia or the loss of skeletal muscle is highly prevalent in many diseases, including short bowel syndrome (SBS). While adaptation is more likely in SBS patients with a colon-in-continuity, the consequences and underlying mechanisms are unclear. An overabundance of fecal Lactobacillus was found but not yet linked to adaptation or sarcopenia. The objectives are to study the evolution of sarcopenia and the link with intestinal adaptation in SBS.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: No
View:

• Age ≥18 years old

• SBS diagnosis validated by small bowel length and either type 1 (enterostomy), type 2 or 3 (jejuno-colic or -ileal anastomosis)

• Patient not objecting to the collection of personal data as part of the study

Locations
Other Locations
France
Service de Coprologie Fonctionnelle Hôpital Pitié-Salpêtrière
Recruiting
Paris
Contact Information
Primary
Nathalie KAPEL, MPharma PhD
nathalie.kapel@aphp.fr
+33 1 42 16 26 56
Backup
Frasisca JOLY, MD PhD
francisca.joly@aphp.fr
+33 1 40 87 53 32
Time Frame
Start Date: August 18, 2022
Estimated Completion Date: July 31, 2024
Participants
Target number of participants: 100
Treatments
SBS patients
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov

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