Summary: Background:~People with sickle cell disease (SCD) have problems with their heart, brain, kidneys, liver, and lungs as they age. These problems may improve after transplant. Researchers want to learn how and why this happens.~Objective:~To study the benefits of treatments that are intended to cure SCD.~Eligibility:~People aged 18 and older with SCD who are either receiving curative therapy in the n...