Efficacy of omalizumab in an atopic young adult with asthma and eosinophilic chronic rhinosinusitis with nasal polyps.

Journal: European Review For Medical And Pharmacological Sciences
Treatment Used: Omalizumab
Number of Patients: 1
Published:
MediFind Summary

Summary: This article reviewed the case of a patient with eosinophilic chronic rhinosinusitis with nasal polyps (type of airway disease involving nasal inflammation with soft, painless, noncancerous growths on the lining of the nasal passages or sinuses; ECRSwNP) and asthma (condition in which airways narrow and swell and may produce extra mucus) treated with omalizumab.

Conclusion: Omalizumab regulated nasal symptoms for more than a year and with good control of the recalcitrant (difficult to treat) pattern when combined with endoscopic sinus surgery (surgical procedure that involves the opening of the passages of the paranasal sinuses to allow for proper drainage).

Abstract

Objective: Chronic rhinosinusitis (CRS) presents a multifactorial etiology due to interactions between the immune host system and external agents. It can be classified into two phenotypes based on the presence or absence of polypoid neoformation (respectively CRSwNP and CRSsNP). According to EPOS2020, CRS is now classified into two endotypes, eosinophilic (ECRS) and non-eosinophilic (non-ECRS), based on eosinophil tissue count (more than 10 eosinophils per High Power Field, HPF). Case presentation: We present the case of a 31-year-old man affected by recalcitrant ECRSwNP and asthma.

Results: He was treated with a combination of omalizumab and endoscopic sinus surgery. This combination led to a reduction in blood eosinophils, modified Lund-Kennedy endoscopic score, Lund-Mackay score, and Sino-Nasal Outcome Test (SNOT-22), almost 6 months after surgery.

Conclusions: In this clinical case, omalizumab regulated nasal symptoms for more than a year and with good control of the recalcitrant pattern when combined with ESS.

Authors
G Fadda, A Galizia, L Maugeri, R Canevari, E Crosetti, G Cavallo

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