Learn About Sjogren Syndrome

What is the definition of Sjogren Syndrome?

Sjögren syndrome is a disorder whose main features are dry eyes and a dry mouth. The condition typically develops gradually beginning in middle adulthood but can occur at any age.

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What are the causes of Sjogren Syndrome?

Sjögren syndrome is thought to result from a combination of genetic and environmental factors; however, no associations between specific genetic changes and the development of Sjögren syndrome have been confirmed. Researchers believe that variations in many genes affect the risk of developing Sjögren syndrome, but that development of the condition may be triggered by something in the environment. In particular, viral or bacterial infections, which activate the immune system, may have the potential to encourage the development of Sjögren syndrome in susceptible individuals. The genetic variations that increase susceptibility may reduce the body's ability to turn off the immune response when it is no longer needed.

How prevalent is Sjogren Syndrome?

Sjögren syndrome is a relatively common disorder; it occurs in 0.1 to 1 percent of the population. It is difficult to determine the exact prevalence because the characteristic features of this disorder, dry eyes and dry mouth, can also be caused by many other conditions. Women develop Sjögren syndrome about 10 times more often than men; the specific reason for this difference is unknown but likely involves the effects of sex hormones on immune system function.

Is Sjogren Syndrome an inherited disorder?

A predisposition to develop autoimmune disorders can be passed through generations in families. Relatives of people with Sjögren syndrome are at an increased risk of developing autoimmune diseases, although they are not necessarily more likely to develop Sjögren syndrome in particular. The inheritance pattern of this predisposition is unknown.

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What are the latest Sjogren Syndrome Clinical Trials?
Descriptive Study of Variations in Serum Translocation Markers of the Intestinal Microbiota in Patients With Gougerot-Sjögren Syndrome According to Disease Activity
Summary: Gougerot-Sjögren syndrome or Sjögren syndrome is a chronic autoimmune disease belonging to connectivitis, the classic triad of symptoms being the association of a sicca syndrome (generally predominant in the mouth and / or ocular, but also present at the cutaneous, vaginal or tracheal level), diffuse arthromyalgia and marked fatigue. The study investigators hypothesize that changes in the gut micr...
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An Open-label, Non-randomized, Biopsy-based Mechanistic Study on Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Ianalumab in Patients With Sjögren's Syndrome
Summary: This study aims at elucidating the mechanism of action of ianalumab in salivary glands and explore relationships with clinical assessments
Who are the sources who wrote this article ?

Published Date: December 09, 2021Published By: National Institutes of Health

What are the Latest Advances for Sjogren Syndrome?
Lacrimal gland injection of platelet rich plasma for treatment of severe dry eye: a comparative clinical study.
Summary: Lacrimal gland injection of platelet rich plasma for treatment of severe dry eye: a comparative clinical study.
Eltrombopag improves refractory thrombocytopenia in patients with Sjögren's syndrome.
Summary: Eltrombopag improves refractory thrombocytopenia in patients with Sjögren's syndrome.
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CO2-Laser therapy and Genitourinary Syndrome of Menopause: A Systematic Review and Meta-Analysis.
Summary: CO2-Laser therapy and Genitourinary Syndrome of Menopause: A Systematic Review and Meta-Analysis.