Phenotype, Genotype & Biomarkers in ALS and Related Disorders

Status: Enrolling by invitation
Location: See all (15) locations...
Study Type: Observational
SUMMARY

The goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA), and frontotemporal dementia (FTD); and (2) to develop biomarkers that might be useful in aiding therapy development for this group of disorders.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: Accepts Healthy Volunteers
View:

• Member of at least one of the following categories:

• Individuals with a clinical diagnosis of ALS or a related disorder, including FTD, HSP, PLS, PMA and MSP (sporadic or familial).

• Family member of an enrolled affected individual.

• Able and willing to comply with relevant procedures.

Locations
United States
California
Stanford University
Palo Alto
University of California San Diego (UCSD)
San Diego
California Pacific Medical Center (CPMC)
San Francisco
Florida
University of Miami
Miami
Iowa
University of Iowa
Iowa City
Kansas
Kansas University Medical Center (KUMC)
Kansas City
Minnesota
Twin Cities ALS Research Consortium
Minneapolis
North Carolina
Wake Forest University
Winston-salem
Ohio
Cleveland Clinic
Cleveland
Pennsylvania
University of Pennsylvania
Philadelphia
Texas
University of Texas Southwestern (UTSW)
Dallas
University of Texas Health Science Center San Antonio (UTHSCSA)
San Antonio
Virginia
University of Virginia (UVA)
Charlottesville
Other Locations
Germany
Eberhard Karls University of Tübingen
Tübingen
South Africa
University of Cape Town
Cape Town
Time Frame
Start Date: April 2015
Estimated Completion Date: July 2025
Participants
Target number of participants: 700
Treatments
Affected
Affected with any of the diseases that are the focus of study by the CReATe Consortium, including ALS, ALS-FTD, HSP, PLS, PMA and MSP.
Unaffected
Unaffected family members of enrolled affected individuals.
Sponsors
Collaborators: National Institute of Neurological Disorders and Stroke (NINDS), ALS Association, St. Jude Children's Research Hospital, National Center for Advancing Translational Sciences (NCATS)
Leads: University of Miami

This content was sourced from clinicaltrials.gov

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