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Last Updated: 01/06/2023

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Imaging Biomarkers in Spastic Paraplegia Type 5

Summary: This is a research study aiming to identify imaging biomarkers in patients diagnosed with spastic paraplegia type 5 (SPG5)

PCSK9 Inhibitor Treatment for Patients With Hereditary Spastic Paraplegia Type 5

Summary: Spastic paraplegia type 5 (SPG5) is a rare subtype of hereditary spastic paraplegia, a highly heterogeneous group of neurodegenerative disorders defined by progressive neurodegeneration of the corticospinal tract motor neurons. SPG5 is caused by recessive mutations in the gene CYP7B1 encoding oxysterol-7a-hydroxylase. This enzyme is involved in the degradation of cholesterol into primary bile acid...

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Last Updated: 01/06/2023