What is the definition of Transient Neonatal Diabetes Mellitus?

Transient neonatal diabetes mellitus (TNDB) is a type of diabetes that appears within the first few weeks of life but is transient; affected infants go into remission within a few months, with possible relapse to permanent diabetes in adolescence or adulthood. Affected individuals have slow growth before birth followed by hyperglycemia, dehydration and failure to thrive in infancy. Approximately 70% of cases are caused by the overactivity of certain genes in a region of the long (q) arm of chromosome 6 called 6q24. These cases are referred to as 6q24-related TNDB; most (but not all) of these cases are not inherited. Other genetic causes include mutations in the KCNJ11 and ABCC8 genes, which usually cause permanent neonatal diabetes. Treatment may include rehydration and intravenous insulin at the time of diagnosis, followed by subcutaneous insulin.

What are the alternative names for Transient Neonatal Diabetes Mellitus?

  • TNDM1
  • TNDM
  • DMTN
  • Diabetes mellitus, transient neonatal
  • Chromosome 6-associated transient diabetes mellitus
  • Diabetes mellitus, 6q24-related transient neonatal
  • Journal: European journal of endocrinology
  • Published —
Differences between transient neonatal diabetes mellitus subtypes can guide diagnosis and therapy.
  • Condition: Gestational Diabetes
  • Journal: The Cochrane database of systematic reviews
  • Treatment Used: Probiotics
  • Number of Patients: 695
  • Published —
In this study, researchers evaluated the safety and effectiveness of treating gestational diabetes with probiotics.