Characterization of Insulin Action and Dopamine-signaling in the Human Brain of Normal Weight and Obese Subjects by [11C]-Raclopride-PET/MRT

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Cerebral insulin resistance plays an important role in the development of obesity and diabetes mellitus type 2. The aim of this project is to examine the effect of human nasal insulin on the dopaminergic system. Therefore, characteristics of cerebral dopamine receptors before and after administration of nasal insulin vs. placebo shall be analyzed in a randomized way. Moreover, the investigators plan to examine the insulin action on cortical and subcortical activation in humans and the interaction of dopamine metabolism with [11C]-Raclopride-PET/MRI. By performing fMRI measurements, insulin sensitivity of the central nervous system can be investigated simultaneously. Recruiting is planed as a two-step process.First 12 normal-weight (BMI 20-25 kg/m²) men should be examined. If first results show a insulin-dependent effect on the availability of dopamine receptors in the human brain, recruitment of 12 overweight men will get started.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 20
Maximum Age: 40
Healthy Volunteers: Accepts Healthy Volunteers
View:

• Understand and voluntarily sign an informed consent document prior to any study related assessments/procedures.

• Intake of any medication

• HbA1C <6%

• BMI 20-25 kg/m²

• Clinical routine blood parameters within the normal ranges

• All participants must agree to get informed of unexpected detected, clinical relevant findings.

Locations
Other Locations
Germany
University of Tuebingen, Department of Internal Medicine IV
Recruiting
Tuebingen
Contact Information
Primary
Andreas Fritsche, MD
andreas.fritsche@med.uni-tuebingen.de
+49 7071 29 82714
Time Frame
Start Date: February 20, 2017
Estimated Completion Date: December 31, 2023
Participants
Target number of participants: 24
Treatments
Placebo Comparator: Placebo
Intranasal placebo administration
Active Comparator: Intranasal insulin
Intranasal insulin administration
Sponsors
Leads: University Hospital Tuebingen

This content was sourced from clinicaltrials.gov

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