Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy.

Journal: Nature Reviews. Nephrology
Treatment Used: Non-Kidney Replacement Therapy (NKRT) and Kidney Replacement Therapies (KRTs)
Number of Patients: 0
Published:
MediFind Summary

Summary: This article presents recommendations for the management of hyperammonemia requiring kidney replacement therapy (KRT) in pediatric populations.

Conclusion: Prompt treatment of hyperammonemia in pediatric patients with kidney replacement therapy and/or non-kidney replacement therapy, the choice of which depends on the ammonia concentrations and presenting symptoms of the patient, is crucial.

Abstract

Hyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea cycle disorders or organic acidaemias. Few studies have assessed the role of extracorporeal therapies in the management of hyperammonaemia in neonates and children. Moreover, consensus guidelines are lacking for the use of non-kidney replacement therapy (NKRT) and kidney replacement therapies (KRTs, including peritoneal dialysis, continuous KRT, haemodialysis and hybrid therapy) to manage hyperammonaemia in neonates and children. Prompt treatment with KRT and/or NKRT, the choice of which depends on the ammonia concentrations and presenting symptoms of the patient, is crucial. This expert Consensus Statement presents recommendations for the management of hyperammonaemia requiring KRT in paediatric populations. Additional studies are required to strengthen these recommendations.

Authors
Rupesh Raina, Jirair Bedoyan, Uta Lichter Konecki, Philippe Jouvet, Stefano Picca, Nicholas Mew, Marcel Machado, Ronith Chakraborty, Meghana Vemuganti, Manpreet Grewal, Timothy Bunchman, Sidharth Sethi, Vinod Krishnappa, Mignon Mcculloch, Khalid Alhasan, Arvind Bagga, Rajit Basu, Franz Schaefer, Guido Filler, Bradley Warady

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