Learn About Van Der Woude Syndrome

What is the definition of Van Der Woude Syndrome?

Van der Woude syndrome is a condition that affects the development of the face. Many people with this disorder are born with a cleft lip, a cleft palate (an opening in the upper lip or roof of the mouth), or both. Affected individuals usually have depressions (pits) near the center of the lower lip, which may appear moist due to the presence of salivary and mucous glands in the pits. Small mounds of tissue on the lower lip may also occur. In some cases, people with van der Woude syndrome have missing teeth.

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What are the causes of Van Der Woude Syndrome?

Mutations in the IRF6 gene cause van der Woude syndrome. The IRF6 gene provides instructions for making a protein that plays an important role in early development. This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of particular genes.

How prevalent is Van Der Woude Syndrome?

Van der Woude syndrome is believed to occur in 1 in 35,000 to 1 in 100,000 people, based on data from Europe and Asia. Van der Woude syndrome is the most common cause of cleft lip and palate resulting from variations in a single gene, and this condition accounts for approximately 1 in 50 such cases.

Is Van Der Woude Syndrome an inherited disorder?

This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In most cases, an affected person has one parent with the condition. Occasionally, an individual who has a copy of the altered gene does not show any signs or symptoms of the disorder.

Who are the top Van Der Woude Syndrome Local Doctors?
Distinguished
Highly rated in
4
conditions

School Of Public Health

Addis Ababa, AA, ET 

Mekonen Eshete is in Addis Ababa, Ethiopia. Eshete is rated as a Distinguished expert by MediFind in the treatment of Van Der Woude Syndrome. They are also highly rated in 4 other conditions, according to our data. Their top areas of expertise are Van Der Woude Syndrome, Popliteal Pterygium Syndrome, Cleft Lip and Palate, and Pterygium.

Distinguished
Highly rated in
3
conditions

Division Of Orthodontic And Pediatric Dentistry

Stockholm, AB, SE 

Marie Pegelow is in Stockholm, Sweden. Pegelow is rated as a Distinguished expert by MediFind in the treatment of Van Der Woude Syndrome. She is also highly rated in 3 other conditions, according to our data. Her top areas of expertise are Van Der Woude Syndrome, Maxillary Double Lip, Popliteal Pterygium Syndrome, and Syndactyly.

 
 
 
 
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Distinguished
Highly rated in
4
conditions

University Of Lagos

Lagos, LA, NG 

Wasiu Adeyemo is in Lagos, Nigeria. Adeyemo is rated as a Distinguished expert by MediFind in the treatment of Van Der Woude Syndrome. They are also highly rated in 4 other conditions, according to our data. Their top areas of expertise are Cleft Lip and Palate, Van Der Woude Syndrome, Popliteal Pterygium Syndrome, and Pyogenic Granuloma.

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Who are the sources who wrote this article ?

Published Date:updated Last, April

Published By: National Institutes of Health

What are the Latest Advances for Van Der Woude Syndrome?
Surgical, Speech, and Audiologic Outcomes in Patients With Orofacial Cleft and Van der Woude Syndrome.
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