Linear accelerator stereotactic radiosurgery can modulate the clinical course of Hemangioblastoma: Case series and review of the literature.

Journal: Journal Of Clinical Neuroscience : Official Journal Of The Neurosurgical Society Of Australasia
Treatment Used: Linear Accelerator Stereotactic Radiosurgery
Number of Patients: 14
MediFind Summary

Overview: This study tested the safety and efficacy of using linear accelerator stereotactic radiosurgery to treat patients with hemangioblastoma.

Conclusion: The study found that tumor control was observed in 87% of patients and disease control was achieved in 78.6% of patients after resection.


Hemangioblastomas (HB) are benign low grade vascular tumors most frequently occurring in the cerebellum, brain stem, and spinal cord. Often associated with Von Hippel Lindau disease (VHL), the lesions are often multifocal requiring complex resection and are difficult to control. Linear Accelerator (LINAC) Stereotactic Radiosurgery (SRS) has been demonstrated to provide additional tumor control. In this case series, we present our multi-center experience utilizing LINAC SRS in fourteen patients with 23 lesions. We observed a tumor control rate of 87% and found interval changes in the peritumoral enhancement to correlate with treatment outcome. In our study, SRS treatment was also well-tolerated in both cystic and noncystic patients with multifocal disease. Disease control was achieved in all but three patients post-resection and no longitudinal radiation-induced secondary malignancy was observed. SRS response correlated highly with lesion size and radiation dose. We conclude that LINAC SRS is safe and effective for patients with HB and should be considered in addition to surgery in asymptomatic, VHL patients, deep seated lesions and isolated lesions.

Z Zibly, Z Cohen, A Peled, L Zach, U Nissim, Moshe Attia, Christian Graves, K Camphausen, R Spiegelman

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