WAGR syndrome is a disorder that affects many body systems and is named for its main features: Wilms tumor, aniridia, genitourinary anomalies, and intellectual disability (formerly referred to as mental retardation).
WAGR syndrome is caused by a deletion of genetic material on the short (p) arm of chromosome 11. The size of the deletion varies among affected individuals.
The prevalence of WAGR syndrome ranges from 1 in 500,000 to one million individuals. It is estimated that one-third of people with aniridia actually have WAGR syndrome. Approximately 7 in 1,000 cases of Wilms tumor can be attributed to WAGR syndrome.
Most cases of WAGR syndrome are not inherited. They result from a chromosomal deletion that occurs as a random event during the formation of reproductive cells (eggs or sperm) or in early fetal development. Affected people typically have no history of the disorder in their family.
Tatyana Vasilyeva is in Moscow, Russian Federation. Vasilyeva is rated as an Elite expert by MediFind in the treatment of WAGR Syndrome. She is also highly rated in 3 other conditions, according to our data. Her top areas of expertise are WAGR Syndrome, Aniridia, Wilms Tumor, and WT1-Related Wilms Tumor Syndromes.
Rena Zinchenko is in Moscow, Russian Federation. Zinchenko is rated as an Elite expert by MediFind in the treatment of WAGR Syndrome. She is also highly rated in 5 other conditions, according to our data. Her top areas of expertise are Aniridia, WAGR Syndrome, Cystic Fibrosis, and Familial Deafness.
Fiona Kelly-Blanco is in Madrid, Spain. Kelly-Blanco is rated as a Distinguished expert by MediFind in the treatment of WAGR Syndrome. She is also highly rated in 11 other conditions, according to our data. Her top areas of expertise are WAGR Syndrome, Gillespie Syndrome, Aniridia, and Retinopathy Pigmentary Mental Retardation.
Published Date: December 01, 2014Published By: National Institutes of Health