Waterhouse-Friderichsen syndrome (WFS) is a group of symptoms resulting from the failure of the adrenal glands to function normally as a result of bleeding into the gland.
Fulminant meningococcemia - Waterhouse-Friderichsen syndrome; Fulminant meningococcal sepsis - Waterhouse-Friderichsen syndrome; Hemorrhagic adrenalitis
The adrenal glands are two triangle-shaped glands. One gland is located on top of each kidney. The adrenal glands produce and release different hormones that the body needs to function normally. The adrenal glands can be affected by many diseases, such as infections like WFS.
WFS is caused by severe infection with meningococcus bacteria or other bacteria, such as:
Symptoms occur suddenly. They are due to the bacteria growing (multiplying) inside the body. Symptoms include:
Infection with bacteria causes bleeding throughout the body, which causes:
Bleeding into the adrenal glands causes adrenal crisis, in which enough adrenal hormones are not produced. This leads to symptoms such as:
Antibiotics are started right away to treat the bacterial infection. Glucocorticoid medicines will also be given to treat adrenal gland insufficiency. Supportive treatments will be needed for other symptoms.
WFS is fatal unless treatment for the bacterial infection is started right away and glucocorticoid drugs are given.
To prevent WFS caused by meningococcal bacteria, a vaccine is available.
Stephens DS. Neisseria meningitides. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier Saunders; 2020:chap 211.
Newell-Price JDC, Auchus RJ. The adrenal cortex. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 15.
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