Udall Project 1 Aim 4
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
By defining the strength and direction of connectivity patterns at rest and during movement across the basal ganglia-thalamocortical (BGTC) network we will characterize the role of individual circuits in motor performance and cognitive function, paving the way for future development of optimization algorithms for DBS that take advantage of this understanding.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Healthy Volunteers: f
View:
• Implanted with a DBS system
• Existing 7T imagery (either done as standard-of-care or done as part of Noam Harel's study, IRB #1210M22183)
• Diagnosed with idiopathic Parkinson's Disease
• Minimum age 21 years
Locations
United States
Minnesota
University Of Minnesota
RECRUITING
Minneapolis
Contact Information
Primary
Niecy Beltz
beltz070@umn.edu
612-626-5711
Time Frame
Start Date: 2024-03-05
Estimated Completion Date: 2027-03-01
Participants
Target number of participants: 100
Treatments
Group 1
Patients will make one visit to the M Health Clinical Research Unit (CRU) after overnight withdrawal of PD medications (still on-DBS) and undergo motor and cognitive assessments in the following three conditions:~1. clinically-optimized stimulation~2. model-based stimulation directed towards motor subregions of STN and GPi~3. model-based stimulation directed towards associative/limbic subregions of STN/GPi~Randomized to start with condition1 assessment
Group 2
Patients will make one visit to the M Health Clinical Research Unit (CRU) after overnight withdrawal of PD medications (still on-DBS) and undergo motor and cognitive assessments in the following three conditions:~1. clinically-optimized stimulation~2. model-based stimulation directed towards motor subregions of STN and GPi~3. model-based stimulation directed towards associative/limbic subregions of STN/GPi~Randomized to start with condition 2 assessment
Group 3
Patients will make one visit to the M Health Clinical Research Unit (CRU) after overnight withdrawal of PD medications (still on-DBS) and undergo motor and cognitive assessments in the following three conditions:~1. clinically-optimized stimulation~2. model-based stimulation directed towards motor subregions of STN and GPi~3. model-based stimulation directed towards associative/limbic subregions of STN/GPi~Randomized to start with condition 3 assessment
Related Therapeutic Areas
Sponsors
Leads: University of Minnesota