Utility of Hyperpolarized 13C-Pyruvate Metabolic Magnetic Resonance Imaging in the Diagnosis of Early Cerebral Metabolic Crisis After Traumatic Brain Injury

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1
SUMMARY

The purpose of this study is to examine the safety and feasibility of using hyperpolarized metabolic MRI to study early brain metabolism changes in subjects presenting with head injury and suspected non-penetrating traumatic brain injury (TBI). This study will also compare HP pyruvate MRI-derived metrics in TBI patients with healthy subjects as well as Subarachnoid hemorrhage (SAH) patients to better understand if metabolic Magnetic resonance imaging scan (MRI) can improve our ability to diagnose a TBI. The FDA is allowing the use of hyperpolarized \[1-13C\] pyruvate (HP 13C-pyruvate) in this study. Up to 15 patients (5 with TBI, 5 with SAH, and 5 healthy volunteers) may take part in this study at the University of Maryland, Baltimore (UMB).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
View:

• History of acute head injury with or suspected non-penetrating acute TBI

• Suitable to undergo contrast-enhanced MRI

• Negative serum pregnancy test

Locations
United States
Maryland
University of Maryland Baltimore
RECRUITING
Baltimore
Contact Information
Primary
Rosy Linda Njonkou Tchoquessi
rnjonkou@som.umaryland.edu
410-706-0943
Time Frame
Start Date: 2023-10-26
Estimated Completion Date: 2027-11-26
Participants
Target number of participants: 15
Treatments
Experimental: Metabolic MRI in traumatic brain injury patients
Perform metabolic magnetic resonance imaging on patients who have traumatic brain injury to understand early brain metabolism changes in this population
Experimental: Metabolic MRI in subarachnoid hemorrhage patients
Perform metabolic magnetic resonance imaging on patients who have subarachnoid hemorrhage to understand early brain metabolism changes in this population
Experimental: Metabolic MRI in healthy volunteers
Perform metabolic magnetic resonance imaging on healthy volunteers to understand early brain metabolism changes in this population
Sponsors
Leads: University of Maryland, Baltimore

This content was sourced from clinicaltrials.gov

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