Development and Validation of a Prediction Model for Adverse Pregnancy Outcomes in Women With Aplastic Anemia

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Aplastic anemia (AA) is a rare haematologic disorder characterized by bone marrow failure and pancytopenia. Its occurrence during pregnancy is exceedingly rare but poses significant risks, including maternal hemorrhage, infections, and perinatal complications such as preterm birth and fetal growth restriction. Consequently, pregnancy with AA is highly perilous for both mothers and infants. Early management is critical to ensure the health of both the mother and the baby. However, there are currently no predictive tools available to assess adverse outcomes in pregnant women with AA. Our center plans to conduct a multicenter, combined retrospective and prospective cohort study.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 20
Maximum Age: 50
Healthy Volunteers: f
View:

• pregnant women who had aplastic anemia before pregnancy

• pregnant women with newly diagnosed aplastic anemia during pregnancy

Locations
Other Locations
China
Peking University People's Hospital
RECRUITING
Beijing
Contact Information
Primary
Xiaohui Zhang, MD
zhangxh@bjmu.edu.cn
+8613522338836
Backup
Qiuyu Guo, MD
qiuyu_guo@163.com
+8613661094882
Time Frame
Start Date: 2025-11-27
Estimated Completion Date: 2030-12-31
Participants
Target number of participants: 300
Treatments
with adverse pregnancy outcomes
without adverse pregnancy outcomes
Sponsors
Collaborators: Peking Union Medical College Hospital, Peking University First Hospital, Lanzhou University Second Hospital, Second Xiangya Hospital of Central South University, General Hospital of Ningxia Medical University, Qilu Hospital of Shandong University, Shanxi Provincial People's Hospital, The Affiliated Hospital of Inner Mongolia Medical University, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, The First Affiliated Hospital of Zhengzhou University, Shanxi Bethune Hospital, The Third Affiliated Hospital of Guangzhou Medical University, First Affiliated Hospital of Zhejiang University, Peking University Third Hospital, The First Affiliated Hospital of Soochow University, The First Affiliated Hospital of Anhui Medical University, Tianjin Medical University General Hospital, Yantai Yuhuangding Hospital, First Affiliated Hospital of Harbin Medical University, Wuhan TongJi Hospital, Chinese PLA General Hospital, Shandong Provincial Hospital
Leads: Peking University People's Hospital

This content was sourced from clinicaltrials.gov