A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction

Status: Recruiting
Location: See location...
Intervention Type: Drug, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Among patients with stable ischemic heart disease who are referred for coronary angiography, a substantial proportion have non-obstructive coronary artery disease (CAD). Ischemia based on symptoms or stress testing may be due to coronary microvascular dysfunction in up to 40% of these patients. However, the mechanisms and optimal treatment of coronary microvascular dysfunction are unknown. Aberrant platelet activity and inflammation have been hypothesized as mechanisms of microvascular dysfunction. Investigators plan to evaluate association between platelet activity, inflammation, and coronary microvascular dysfunction in stable women referred for coronary angiography, and to identify non-invasive correlates of coronary microvascular dysfunction in these patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 125
Healthy Volunteers: f
View:

• Adult women age ≥18 years referred for coronary angiography

• Stable ischemic heart disease, defined by ischemic symptoms and/or myocardial ischemia by stress testing

• Administration of aspirin therapy prior to cardiac catheterization

Locations
United States
New York
New York University School of Medicine
RECRUITING
New York
Contact Information
Primary
Nathaniel Smilowitz
Nathaniel.Smilowitz@nyulangone.org
212-263-5656
Time Frame
Start Date: 2018-06-29
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 175
Treatments
Experimental: Non-Obstructive CAD
After diagnostic coronary angiography, invasive measures of coronary microvascular physiology will be obtained. Blood will be collected for platelet activity, inflammation and isolation of coronary endothelial cells.
Related Therapeutic Areas
Sponsors
Leads: NYU Langone Health

This content was sourced from clinicaltrials.gov