Comparison of Remimazolam vs. Midazolam for Sedation During Cataract Surgery

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The goal of this study is to assess any post operative cognitive changes following benzodiazepine administration during cataract surgery. The investigators will compare effects of Midazolam vs. Remimazolam on cognition at the time of discharge from the post operative care unit and the next day following surgery. Cognitive changes will be assessed by administration of Montreal Cognitive Assessment (MoCA). Participants will: 1. Complete MoCA testing prior to surgery 2. Randomize in either Midazolam or study drug Remimazolam 3. Complete MoCA testing after surgery at the time of discharge in the post anesthesia care unit and the next day of surgery at the time of post operative surgical visit. 4. Complete Patient Satisfaction Survey at the time of discharge from the Post Anesthesia Care Unit (PACU)

Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Healthy Volunteers: f
View:

• Adult patients age \> 65 years undergoing first eye cataract surgery under local topical anesthesia at the University of California, Los Angeles (UCLA).

• Both male and female patients

• American Society of Anesthesiologists Class 2, 3, and 4.

Locations
United States
California
Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine
RECRUITING
Los Angeles
Contact Information
Primary
Zhuang T Fang, MD
ZFang@mednet.ucla.edu
310-267-8946
Backup
Stephanie-Dee Sarovich, BS
ssarovich@mednet.ucla.edu
424-832-6842
Time Frame
Start Date: 2025-03-10
Estimated Completion Date: 2026-01
Participants
Target number of participants: 120
Treatments
Experimental: Intervention
Patients assigned to the study group will receive Remimazolam.
Active_comparator: Control
Patients assigned to the control group will receive Midazolam.
Related Therapeutic Areas
Sponsors
Leads: University of California, Los Angeles

This content was sourced from clinicaltrials.gov

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