Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated With Invasive Mechanical Ventilation : INASED Study
Status: Recruiting
Location: See all (12) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The objective of the study is to determine the impact on the frequency of occurrence of delirium of an early inhaled sedation strategy (from induction in rapid sequence if intubation in intensive care, or from admission if intubated in pre -hospital) by Isoflurane using an ANACONDA ™ type system, compared to a conventional intravenous sedation strategy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patient aged 18 and over
• Patient requiring mechanical ventilation for at least 24 hours
• The patient requires continuous and immediate sedation for more comfort, safety and to facilitate the administration of survival measures.
• Consent obtained from patient or relative
Locations
Other Locations
France
CH Bourges
RECRUITING
Bourges
CHU de Brest
RECRUITING
Brest
CH Corbeil Essonnes
RECRUITING
Corbeil-essonnes
CH Le Mans
RECRUITING
Le Mans
GHBS Lorient
RECRUITING
Lorient
CH Melun
RECRUITING
Melun
CHU Montpellier
SUSPENDED
Montpellier
CH Morlaix
RECRUITING
Morlaix
CHU Poitiers
RECRUITING
Poitiers
CHU Rennes
RECRUITING
Rennes
CHU Tours
RECRUITING
Tours
CHU Tours - Réanimation Chirurgicale
NOT_YET_RECRUITING
Tours
Contact Information
Primary
Pierre Bailly, MD
pierre.bailly@chu-brest.fr
02 98 34 71 81
Time Frame
Start Date: 2020-08-06
Estimated Completion Date: 2026-08
Participants
Target number of participants: 250
Treatments
Active_comparator: Usual sedation
Sedation according to a written, standardized Nurse management protocol using at least one sedative drug (propofol) and one analgesic drug.
Experimental: Inhaled sedation
Sedation by inhalation of halogenated gas (Isoflurane) delivered by the Anesthetic-Conserving Device (ACD) system ANACONDA ™ associated with the administration of an analgesic drug.
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Brest