Pilot Randomized Trial of Intravenous or Oral Acetaminophen After Cardiac Surgery
Who is this study for? Patients with Delirium
What treatments are being studied? Acetaminophen
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
Double blind double dummy of Intravenous Acetaminophen and oral acetaminophen placebo versus IV placebo versus oral acetaminophen in patients following cardiac surgery. The primary endpoint is development of Delirium during the post-operative stay.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• subjects \> 18 years of age undergoing elective aortocoronary bypass, single valve replacement or single valve and aortocoronary bypass surgery
Locations
Other Locations
Canada
McGill University Health Centre
RECRUITING
Montreal
Montreal Heart Institute
RECRUITING
Montreal
Contact Information
Primary
sheldon magder, MD
sheldon.magder@mcgill.ca
5149475918
Time Frame
Start Date: 2023-06-06
Estimated Completion Date: 2024-12-15
Participants
Target number of participants: 900
Treatments
Experimental: Intravenous Acetaminophen
subjects will receive IV acetaminophen and a placebo oral acetaminophen starting immediately after surgery and for 8 doses
Active_comparator: Oral acetaminophen
subjects will receive a placebo for IV acetaminophen and active oral acetaminophen starting immediately after surgery and for 8 doses
Related Therapeutic Areas
Sponsors
Collaborators: Canadian Institutes of Health Research (CIHR), University of Manitoba, Montreal Heart Institute
Leads: McGill University Health Centre/Research Institute of the McGill University Health Centre