Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

More than 60% of intensive care unit (ICU) patients are adults ages 60 and older, who are at high risk for ICU-acquired cognitive impairment. After ICU discharge, ICU survivors often experience sleep disturbances and inactivity, and almost 80% of ICU patients experience disturbances in circadian rhythm, which may affect cognitive function. Understanding the optimal, chronotherapeutic timing of cognitive interventions is crucial to promote circadian realignment and cognitive function, and may improve intervention feasibility, acceptability, and efficacy. Specific Aim 1 will determine feasibility, acceptability, and preliminary effect sizes for: 1) a morning session of a computerized cognitive training intervention \[COG\]; and 2) a late afternoon/early evening session of the COG intervention; compared to 3) standard inpatient care/usual care \[UC\]. Specific Aim 2 will examine circadian rhythm parameters to determine the optimal timing of the daily COG intervention. Exploratory Aim 3 will explore if the effects of the COG intervention on cognitive function are mediated by daytime activity, and explore if selected biological and clinical factors moderate intervention effects on cognitive function.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Healthy Volunteers: f
View:

• Age ≥ 60 years

• ICU length of stay ≥ 24 hours

• Active transfer order or expected discharge from ICU to a post-ICU unit

• Fluent in English

• Functional independence prior to hospital admission (Katz Index = 6)

• No suspicion of Alzheimer's disease/dementia

• Current hospitalization at University of Washington Medical Center or Harborview Medical Center

Locations
United States
Washington
University of Washington Medical Center
RECRUITING
Seattle
Contact Information
Primary
Maya N Elias, PhD, MA, RN
mnelias@uw.edu
206-543-8564
Time Frame
Start Date: 2023-11-15
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 40
Treatments
Experimental: COG-AM
30-minute morning session of a laptop-based computerized cognitive training intervention, delivered between the hours of 09:00 AM - 12:00 PM, in addition to UC
Experimental: COG-PM
30-minute afternoon/evening session of a laptop-based computerized cognitive training intervention, delivered between the hours of 15:00 PM - 18:00 PM, in addition to UC
No_intervention: UC
Standard post-ICU inpatient care/usual care, which includes physical/occupational therapy as ordered by treatment team
Related Therapeutic Areas
Sponsors
Collaborators: American Association of Critical Care Nurses
Leads: University of Washington

This content was sourced from clinicaltrials.gov