Safety and Efficacy of Esketamine Combined With Dexmedetomidine for Sedation of Mechanically Ventilated Patients in the ICU: a Prospective, Randomized, Single-center Study
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
A prospective, randomized controlled study was conducted to compare the effects of esketamine combined with dexmedetomidine in the sedation and analgesia treatment of mechanically ventilated patients in the ICU on the time to awaken, time to extubation, time to mechanical ventilation, time in the ICU, and on delirium.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• Mechanically ventilated with oral endotracheal intubation in the ICU;
• Patients aged \>18 years and \<70 years;
• Patients with expected mechanical ventilation time \>24 hours.
Locations
Other Locations
China
The First Affiliated Hospital with Nanjing Medical University
RECRUITING
Nanjing
Contact Information
Primary
Zuo Xiangrong
zuoxiangrong@njmu.edu.cn
+86 13913979197
Time Frame
Start Date: 2022-08-11
Estimated Completion Date: 2024-12-01
Participants
Target number of participants: 100
Treatments
Experimental: Esketamine combined with dexmedetomidine
Esketamine will be administered at 1mg/kg, IVP, then intravenously pumped at 0.25-1.5mg/kg/h in combination with dexmedetomidine 1μg/kg for 20 min, followed by continuous intravenously pumped at 0.2-0.7mg/kg/h, maintaining a RASS score of -2-0.
Active_comparator: Dexmedetomidine
Dexmedetomidine will be administered at 1μg/kg for 20 min, followed by continuous intravenous pumping at 0.2-0.7mg/kg/h to maintain a RASS score of -2-0
Related Therapeutic Areas
Sponsors
Leads: The First Affiliated Hospital with Nanjing Medical University