The Anesthesia Effects of Dexmedetomidine Combined With Desflurane or Propofol in Lobectomy.
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
In one-lung ventilation surgery, compared with dexmedetomidine combined with propofol, dexmedetomidine combined with desflurane may be beneficial to accelerate patients' recovery and reduce postoperative pulmonary complications and does not increase the incidences of delirium and postoperative nausea and vomiting.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients undergoing elective thoracoscopic unilateral lobectomy.
• General anesthesia is required and the expected duration of one-lung ventilation is ≥ 1h.
• American Association of Anesthesiologists (ASA) physical condition classification I-III.
• Patients over 18 years old.
• Voluntary participation and ability to understand and sign the informed consent.
Locations
Other Locations
China
The Second Affiliated Hospital of Chongqing Medical University
RECRUITING
Chongqing
The Second Affiliated Hospital of Chongqing Medical University
RECRUITING
Chongqing
Contact Information
Primary
Yu Chen
cypgxhcj@tom.com
8602362887913
Time Frame
Start Date: 2023-10-21
Estimated Completion Date: 2025-06-30
Participants
Target number of participants: 120
Treatments
Active_comparator: Dexmedetomidine and propofol
After anesthesia induction, dexmedetomidine was infused intravenously at 1 μg/kg within 15 min, then infused at 0.3 μg/kg/h until 30 min before the end of the operation. Propofol was infused intravenously at 4-12mg/kg/h to maintain the depth of anesthesia (patient state index between 25-50 monitored by Masimo SedLine).
Experimental: Dexmedetomidine and desflurane
After anesthesia induction, dexmedetomidine was infused intravenously at 1 μg/kg within 15 min, and then infused at 0.3 μg/kg/h until 30 min before the end of the operation. At the same time, 2.5%-8.5% desflurane was used to maintain the depth of anesthesia (patient state index between 25-50 monitored by Masimo SedLine).
Related Therapeutic Areas
Sponsors
Leads: The Second Affiliated Hospital of Chongqing Medical University