Impact of Desflurane Versus Sevoflurane Anesthesia Maintenance Methods on Incidence of Postoperative Delirium in Elderly Patients
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Advanced age is a consistent risk factor for the incidence of postoperative cognitive decline, which is associated with longer hospital stays, decreased quality of life, and increased mortality. Anaesthetic drugs can also affect postoperative cognition, as their residual effects can alter central nervous system activity. Desflurane and sevoflurane are widely used volatile anesthetics. Choice anesthetics may influence the occurrence of postoperative delirium. However, evidence in this aspect is conflicting.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Maximum Age: 90
Healthy Volunteers: t
View:
• Age ≥ 65 years and \< 90 years;
• Scheduled to undergo non-cardiac or non-neurosurgery with an expected duration of 2 hours or more, under general anesthesia;
• Agree to participate, and give signed written informed consent.
Locations
Other Locations
China
Department of Anesthesiology, West China Hospital
RECRUITING
Chengdu
Contact Information
Primary
Jing Yang, MD,PhD
yangjing@wchscu.cn
+86- 18980602269
Backup
Min Xu
18706782887@163.com
+86-13281155917
Time Frame
Start Date: 2023-09-10
Estimated Completion Date: 2025-09
Participants
Target number of participants: 890
Treatments
Active_comparator: Sevoflurane group
Sevoflurane will be administered by inhalation for anesthesia maintenance. The concentration of inhaled sevoflurane will be adjusted to maintain the bispectral index (BIS) value between 40 and 60. Analgesia will be supplemented with remifentanil, sufentanil. Sevoflurane inhalation will be stopped at the end of surgery.
Experimental: Desflurane group
Desflurane will be administered by inhalation for anesthesia maintenance. The concentration of inhaled sevoflurane will be adjusted to maintain the BIS value between 40 and 60. Analgesia will be supplemented with remifentanil, sufentanil. Desflurane inhalation will be stopped at the end of surgery.
Related Therapeutic Areas
Sponsors
Leads: West China Hospital