Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients：a Single-center, Double- Blind, Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
Delirium is a common consequence of cardiac surgery and associates with poor outcomes. Multiple causes can trigger delirium occurence, and it has been hypothesised that sleep disturbances can be one of them. Dexmedetomidine may be effective in reducing delirium. The aim of this study was to demonstrate preoperative dexmedetomidine nasal spray in cardiac surgery patients can reduce postoperative delirium by improving preoperative sleep.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Aged 18 years or older.
• Cardiac surgery with cardiopulmonary bypass.
• Ability to provide consent.
Locations
Other Locations
China
Xijing Hospital
RECRUITING
Xi'an
Contact Information
Primary
Chong Lei, M.D., phd
crystalleichong@126.com
86-18629011362
Backup
Zefei Zhang, M.D.
zzfanita7@163.com
86-18811797795
Time Frame
Start Date: 2025-03-03
Estimated Completion Date: 2027-03-30
Participants
Target number of participants: 686
Treatments
Experimental: Dexmedetomidine group
The Dexmedetomidine group will receive dexmedetomidine nasal spray （1.5ug/kg, ideal body weight) at the night before surgery and 30 minutes before induction.
No_intervention: Control group
In the control group, the treatment is sodium chloride 0.9% nasal spray. Follows the same rules as in the experimental group.
Related Therapeutic Areas
Sponsors
Leads: Xijing Hospital