Comparative Analysis of Delirium in Older Patients Treated With Selected Antibiotics: a Prospective Cohort Study

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The goal of this observational study is to learn if the use of ceftazidime, cefepime, and ceftriaxone impacts the incidence of delirium in elderly patients (aged 65 and older) with infections. The main questions it aims to answer are: Does the administration of these antibiotics increase the incidence of delirium in elderly patients? How do renal and hepatic dose adjustments affect the likelihood of delirium? Researchers will observe elderly patients receiving either ceftazidime, cefepime, or ceftriaxone for infection management to see if these antibiotics contribute to the onset of delirium, and then assessing the severity of the delirium. Participants will: Be assessed for delirium using the CAM (Confusion Assessment Method) at 2, 4, and 6 days after starting treatment. Have their QSOFA (Quick Sequential Organ Failure Assessment) and NEWS (National Early Warning Score) tracked to evaluate their overall health status. Undergo dose adjustments based on renal and hepatic function as part of their treatment. Use the DRS.R89 score to assess delirium if it occurred.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Healthy Volunteers: f
View:

• Older adult patients aged 65 years or above.

• Hospitalized patients in Alexandria university hospitals diagnosed with infection and treated with selected cephalosporins (Ceftriaxone, Ceftazidime, or Cefepime).

• Patients without a history of Pre-existing delirium prior to hospitalization.

Locations
Other Locations
Egypt
Alexandria Main University Hospitals
RECRUITING
Alexandria
Contact Information
Primary
Rana Kh Draz, Pharm D.
rana.draz90@gmail.com
1096209641
Backup
Noha A Hamdy, Ph.D
noha.alaaeldine@alexu.edu.eg
1005182151
Time Frame
Start Date: 2024-10-01
Estimated Completion Date: 2025-12
Participants
Target number of participants: 120
Treatments
Ceftazidime Group
A cohort of at least 40 older-adult patients (≥65 years) receiving ceftazidime for the treatment of various infections.
Cefepime Group
A group of a minimum of 40 elderly patients treated with cefepime for confirmed or suspected infections.
Ceftriaxone Group
This cohort will include at least 40 older adult inpatients receiving ceftriaxone as part of their anti-infective regimen
Related Therapeutic Areas
Sponsors
Leads: Alexandria University

This content was sourced from clinicaltrials.gov