Neostigmine and Glycopyrrolate for the Treatment of Post Dural Puncture Headache After Known Dural Puncture With a Tuohy Needle: A Pilot Study
Who is this study for? Patients with post-dural puncture headache
What treatments are being studied? Neostigmine+Atropine
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
The purpose of this study is to evaluate Neostigmine and Glycopyrrolate to treat post-dural puncture headache (PDPH) to reduce the proportion of postpartum women with a PDPH requiring epidural blood patch (EBP) who developed a PDPH after accidental dural puncture.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 54
Healthy Volunteers: f
View:
• Post-dural puncture headache (PDPH) after documented dural puncture with Tuohy needle during placement of epidural analgesia for labor and no other explanation for headache (HA).
• Onset of HA within 72 hours of delivery.
Locations
United States
Minnesota
Mayo Clinic in Rochester
RECRUITING
Rochester
Time Frame
Start Date: 2021-11-19
Estimated Completion Date: 2025-12
Participants
Target number of participants: 18
Treatments
Experimental: Postpartum dural puncture headache following dural puncture from Tuohy needle
Subjects identified as experienced a post dural puncture headache after a confirmed dural puncture from a Tuohy needle will receive an IV administration of the study medications neostigmine and glycopyrrolate.
Related Therapeutic Areas
Sponsors
Leads: Mayo Clinic