Lidocaine Infusion As A Treatment Modality For Headache Following Non-Traumatic Subarachnoid Hemorrhage: A Prospective, Single-Center, Observational Cohort Study

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The goal of this observational study is to evaluate intravenous lidocaine efficacy and safety in treating headache following non-traumatic subarachnoid hemorrhage. Through this prospective analysis, the investigators hope to: 1. show that intravenous lidocaine infusion causes a clinically significant reduction in pain scores in patients with moderate/severe headache pain following non-traumatic subarachnoid hemorrhage; 2. show that intravenous lidocaine infusion is safe in treating headache following non-traumatic subarachnoid hemorrhage; 3. and report vasospasm prevalence in the cohort. Participants will receive lidocaine infusion as treatment for non-traumatic subarachnoid hemorrhage headache and provide pain scores (on a numeric pain scale) every two hours the patients are awake for a maximum of seven days. Monitoring for vasospasm will occur as part of the patients regular medical care.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients \> 18 years;

• Have a favorable neurological status defined as Hunt and Hess score ≤ 3 (as it accounts for patient awareness);

• Can communicate numeric pain scores;

• Are diagnosed with non-traumatic subarachnoid hemorrhage

Locations
United States
Kansas
Ascension Via Christi St. Francis
RECRUITING
Wichita
Contact Information
Primary
William L Krogman, MS
wkrogman@kumc.edu
316-268-6156
Time Frame
Start Date: 2025-01-31
Estimated Completion Date: 2028-07
Participants
Target number of participants: 20
Treatments
Lidocaine infusion
Patients will receive a 100 mg intravenous lidocaine bolus followed by an initial infusion at a rate of 2 mg∙kg -1∙h-1 based on ideal body weight. Lidocaine infusions will continue for a minimum of 1 h post-bolus. If headache numeric pain score decreases at all after initiation of infusion, then the rate will drop to 1 mg∙kg -1∙h-1. If headache numeric pain score starts increasing again, then the rate will return to 2 mg∙kg -1∙h-1, otherwise it will remain at 1 mg∙kg -1∙h-1 for up to 48 h.
Related Therapeutic Areas
Sponsors
Leads: University of Kansas Medical Center
Collaborators: Ascension Via Christi Hospitals Wichita, Inc.

This content was sourced from clinicaltrials.gov