Hospital-Based Management of Patients With Chronic Hepatitis B Virus Infection
Since 2022, the Third Affiliated Hospital of Sun Yat-sen University has initiated the Hot Wave Project, a comprehensive hepatitis B infection prevention and management system encompassing patient education, screening, referral, treatment, and follow-up. In 2024, this system was expanded to the Sixth Affiliated Hospital and the Fifth Affiliated Hospital of Sun Yat-sen University, transitioning into a multicenter, hospital-based cohort study on hepatitis B management.The primary objective of this study is to increase the referral rate of HBsAg-positive patients in non-hepatology/non-infectious disease departments to 50%. The secondary objective is to improve the treatment rate of hepatitis B infected patients in non-hepatology/non-infectious disease departments, particularly focusing on the diagnosed but untreated (DBU) population. Furthermore, this study aims to analyze the cost-effectiveness and clinical benefits of in-hospital hepatitis B screening and management strategies.In 2025, a Patient-Reported Outcomes (PRO) sub-study was added to the project to evaluate the impact of antiviral therapy on the Health-Related Quality of Life among a cohort of treatment-naïve patients with chronic hepatitis B.
• HBsAg-positive patients attending non-infectious disease/hepatology departments at three study centers.
⁃ Additional inclusion criteria for the PRO sub-study:
• Age ≥ 18 years;
• Treatment-naïve HBV-infected patients;
• Meet the treatment criteria according to the Chinese Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2022 version);
• Be able to understand the study content, willing to participate, and sign the informed consent;
• Have the ability to complete questionnaires independently or with assistance.