Prospective Study of Autoimmune Endocrine Disease-related Antibodies Before the Start of Immune Checkpoint Inhibitor Therapy

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Promising treatments have been added to the oncologist's arsenal in recent years. Treatments that, unlike conventional chemotherapy, do not aim to destroy cancer cells directly, but rather activate the patient's own immune system to recognize and attack tumor cells again. This new treatment is called immune checkpoint therapy. This involves administering antibodies (large Y-shaped proteins that can stick to the surface of cells) that remove the brakes from the immune system. The disadvantage of this innovative treatment is that the rejuvenated immune system can also attack cells that we want it not to recognize - our own body's cells. This is called autoimmunity. Patients who receive immune checkpoint therapy may suffer from symptoms such as skin rashes, diarrhea, hepatitis or hypothyroidism. The purpose of this study is to find biomarkers predictive of the development of these side effects, and possibly also predict a better outcome of the cancer therapy. The investigators will also look for the presence of antibodies against the endocrine glands (glands that produce hormones, such as the thyroid, adrenal, pituitary, and pancreas) before the start of the immune therapy.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• All subjects eligible for immune checkpoint therapy at the participating study sites. The cohort will consist of all subjects who consent to participate, and to use their information for future research and publication in a scientific journal.

Locations
Other Locations
Belgium
C.H.U. Saint-Pierre
RECRUITING
Brussels
CHU Brugmann
RECRUITING
Brussels
HUB - Institut Jules Bordet
RECRUITING
Brussels
Contact Information
Primary
Jeroen de Filette, MD
Jeroen.DEFILETTE@chu-brugmann.be
024772067
Time Frame
Start Date: 2023-11-14
Estimated Completion Date: 2027-12
Participants
Target number of participants: 500
Treatments
Experimental: immune checkpoint therapy
The study aims to include all subjects eligible for immune checkpoint therapy at the participating study sites.
Related Therapeutic Areas
Sponsors
Leads: Laura ICONARU

This content was sourced from clinicaltrials.gov