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Integrative Epidemiology of Prognosis in Patients With Acute Alcoholic Hepatitis at AP-HP

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Acute alcoholic hepatitis (AAH) is a severe liver disease that often occurs in individuals with prolonged excessive alcohol consumption. Patients face a high risk of liver failure, complications, and death, despite available treatments. Current prognostic scores based on blood tests provide limited accuracy and do not capture the full complexity of the disease. The purpose of this study is to improve the prediction of patient outcomes after a diagnosis of acute alcoholic hepatitis. By integrating clinical, biological, and histological information collected from the AP-HP data warehouse, the investigators aim to identify more reliable prognostic markers. This could help physicians better tailor treatments and improve survival of patients affected by this condition.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adult patients (≥18 years)

• Diagnosis of acute alcoholic hepatitis (ICD10 K701 or occurrence of the terms HAA (French translation of AAH or hépatite alcoolique aiguë (French translation of acute alcoholic hepatitis) in a pathology report, followed by manual verification

Locations
Other Locations
France
Necker Hospital
RECRUITING
Paris
Contact Information
Primary
Vincent MALLET, MD, PhD
vincent.mallet@aphp.fr
01584142453
Backup
Camille Luya-Guedj, MSc
camille.luya-guedj@aphp.fr
0144494327
Time Frame
Start Date: 2024-07-19
Estimated Completion Date: 2025-12
Participants
Target number of participants: 1400
Treatments
Patients with acute alcoholic hepatitis
All adult patients diagnosed with acute alcoholic hepatitis at AP-HP hospitals, identified using ICD-10 codes (K701), pathology reports, and clinical data.
Related Therapeutic Areas
Sponsors
Collaborators: URC-CIC Paris Descartes Necker Cochin, Ministry of Health, France
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov