• 1\. Subject capable of understanding written information ,willing to participate in, and provide a written informed consent;

• 2.Male or female subjects must be at least 18 years old when signing the informed consent;

• 3.The subjects must undergo regular maintenance hemodialysis three times a week for at least three months；

• 4.Dialysate calcium concentration≥1.25 mmol/L (2.5 mEq/L);

• 5.Diagnosed of Secondary Hyperparathyroidism (SHPT), with averaged iPTH ≥400 pg/ml14 days prior to screening;

• 6.Receiving active vitamin D sterols must have had no more than a maximum dose change of 50% within the 1 month prior to screening, remain stable;

• 7.Subject receiving calcium supplements, or phosphate binders must have had no more than a maximum dose change of 50% within the 2 weeks prior to screening, remain stable;