Use of Right Ventricular Conductance Catheter Guidance to Optimise Balloon Pulmonary Angioplasty as a Non Surgical Treatment of Chronic Thromboembolic Pulmonary Hypertension.

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY

Balloon pulmonary angioplasty (BPA) treats patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Intra-procedural markers of success to guide the intervention are lacking. The investigators propose to measure right ventricular (RV) pressure volume loops invasively and measure biomarkers at intervals during the course of a course of BPA. These data will be analysed to define load independent indices of RV functional improvement, cross correlated with biomarker data and be used to calibrate non-invasive assessment of ventriculo-arterial coupling by cardiac magnetic resonance imaging (CMR) to better detect responders of BPA and pulmonary endarterectomy (PEA).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• \>18 years old

• Able to provide informed consent

• Inoperable CTEPH eligible for BPA treatment

Locations
Other Locations
United Kingdom
Royal Papworth Hospital
RECRUITING
Cambridge
Contact Information
Primary
Sarah Fielding, PhD
sarah.fielding2@nhs.net
+441223639960
Time Frame
Start Date: 2022-01-01
Estimated Completion Date: 2024-12-31
Participants
Target number of participants: 20
Treatments
Invasive RV assessment
RV conductance catheter assessment of RV performance
Sponsors
Leads: Papworth Hospital NHS Foundation Trust

This content was sourced from clinicaltrials.gov