Impact of Decreased Venous Return on Supine Blood Pressure

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Many persons with autonomic failure often have high blood pressure when lying down (supine hypertension). This study is exploring the impact of decreased venous return to the heart (achieved by raising the head of the bed) to lessen supine blood pressure. If decreased venous return to the heart is effective at lowering supine blood pressure, these approaches may be utilized to treat supine hypertension non-pharmacologically. Raising the head of the bed decreases the amount of blood returning to the heart due to the effects of gravity. In this case, the decreased blood return to the heart may decrease blood pressure.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:

• Patients with autonomic failure and with supine hypertension from all races

• Males and females, between 18 to 85 years

Locations
United States
Tennessee
Vanderbilt University Medical Center
RECRUITING
Nashville
Contact Information
Primary
Bonnie K Black, RN
bonnie.black@vumc.org
615-343-6862
Backup
Luis E. Okamoto, MD
luis.e.okamoto@vumc.org
(615) 936-6119
Time Frame
Start Date: 2020-08-21
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 44
Treatments
Experimental: Elevation of the whole bed (tilt)
Tilt of the whole bed so that the participant's head is raised by 9 and/or 12 inches.
Experimental: Elevation of the trunk
Elevation of the trunk by tilting just the head of the bed so that the participant's head is raised by 9 and/or 12 inches.
Experimental: Elevation of the whole bed (tilt) - In home
Tilt of the whole bed so that the participant's head is raised by 8 inches.
Experimental: Elevation of the trunk - In home
Elevation of the trunk by raising the head 8 inches on a wedge pillow.
Related Therapeutic Areas
Sponsors
Leads: Vanderbilt University Medical Center

This content was sourced from clinicaltrials.gov