Sleep and Circadian Mechanisms in Hypertension
Status: Recruiting
Location: See location...
Intervention Type: Other, Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study is a mechanistic clinical trial designed to investigate the effects of the circadian system and sleep on non-dipping blood pressure (BP) in people with hypertension (HTN).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 25
Maximum Age: 64
Healthy Volunteers: f
View:
• Ages 25-64
• BMI 18.5-42kg/m2
• Hypertension (average resting blood pressure between 130/80 mmHg and 160/100 mmHg)
Locations
United States
Oregon
Oregon Health and Science University
RECRUITING
Portland
Contact Information
Primary
Nicole Chaudhary, MPH
clinphys@ohsu.edu
5034945536
Time Frame
Start Date: 2022-08-04
Estimated Completion Date: 2028-03-30
Participants
Target number of participants: 32
Treatments
Experimental: Dipping vs non-dipping HTN
Participants will wear an ambulatory blood pressure monitor (SpaceLabs, Inc.) which will take their blood pressure in 20-30-minute intervals for 24-48 hours to determine blood pressure dipping status.~All participants in this arm will complete the experiments in this order:~1. At-home polysomnography;~2. Constant Routine protocol;~3. Rested Wakefulness Trial AND Overnight Sleep Trial (Randomized crossover);~4. Sleep Regularization Trial
Related Therapeutic Areas
Sponsors
Leads: Oregon Health and Science University