Renal Metabolism in Salt-sensitive Human Blood Pressure
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Salt sensitive hypertension is a significant health problem worldwide and a primary modifiable risk factor for renal, cardiovascular, and cerebrovascular diseases. Yet, the underlying mechanisms remain poorly understood. The proposed study determines how renal oxygenation and substrate metabolism differs between individuals with and without salt sensitivity, with the ultimate goal of identifying mechanisms, diagnostic criteria, and treatment strategies for salt sensitive hypertension.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Maximum Age: 65
Healthy Volunteers: f
View:
• English speaking subjects
• With a spectrum of BPs, ranging from those with Elevated BP through Stage 1 HTN, as defined by the 2017 ACC/AHA HTN guidelines
Locations
United States
Wisconsin
Medical College of Wisconsin /Froedtert Hospital
RECRUITING
Milwaukee
Contact Information
Primary
Srividya Kidambi, MD
skidambi@mcw.edu
414-955-6724
Backup
Roland James, MA
rjames@mcw.edu
414-456-4992
Time Frame
Start Date: 2021-11-01
Estimated Completion Date: 2030-01-30
Participants
Target number of participants: 70
Treatments
Active_comparator: Low sodium diet
-Subjects will be randomized to start a low sodium diet (1200 mg/day) for two weeks (this will be followed by a high sodium diet - crossover design)
Active_comparator: high sodium diet
-Subjects will be randomized to start a high sodium diet (4200 mg/day) for two weeks (this will be followed by a low sodium diet - crossover design)
Related Therapeutic Areas
Sponsors
Leads: Medical College of Wisconsin