National Tawan University Hospital
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
Study design: Investigator initiated, single center The study is aimed 1\) To investigate the blood pressure (BP) change to renal nerve stimulation(RNS), and subsequently perform a renal denervation(RDN) procedure 1\) to verify the cutoff value (RNS-induced systolic BP change \<20 mmHg in post-RDN patients) could be a useful clinical endpoint in RDN therapy, and test the hypothesis that intense RDN could improve the efficacy of RDN.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Healthy Volunteers: f
View:
⁃ Patients with hypertension (HTN), including
• 24-hour ambulatory blood pressure \>130/ 80 mmHg
• Age 20-80 years
• Glomerular filtration rate \>45 mL/min
Locations
Other Locations
Taiwan
National Taiwan University Hospital
RECRUITING
Taipei
Time Frame
Start Date: 2022-06-24
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 60
Treatments
Active_comparator: Low RNS-induced SBP change group
25 patients with the RNS-induced systolic BP change \<20mmHg immediately after RDN
Placebo_comparator: High RNS-induced SBP change group
8 patients with the RNS-induced systolic BP change \>20mmHg immediately after RDN
Experimental: intensive RDN group
17 patients with the initial RNS-induced systolic BP change \>20mmHg immediately after RDN, received intensive RDN therapy and let the second RNS-induced systolic BP change \< 20mmHg
Related Therapeutic Areas
Sponsors
Leads: National Taiwan University Hospital