Home Exercise Training in Pediatric Pulmonary Hypertension

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Children with pulmonary hypertension (PH) engage in less physical activity than their peers. This is a concern since adult data support exercise as a non-pharmacologic treatment for PH. Despite adult data, therapeutic exercise has not been widely adopted in pediatric PH. Investigators have previously demonstrated that children with PH have less skeletal muscle mass in association with worse exercise performance. Interventions to increase physical activity and skeletal muscle mass may improve exercise performance and quality of life in children with PH. This study will use wearable activity monitoring devices to promote physical activity in a 16-week pilot intervention in children and teenager with PH.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 8
Maximum Age: 18
Healthy Volunteers: f
View:

• Age 8-18 years

• PH World Health Organization (WHO) diagnostic groups 1, 2, 3, or 4 (pulmonary arterial hypertension, PH due to left heart disease, PH due to lung disease, chronic thromboembolic PH)

• WHO functional class I or II

• Ambulatory status

• Mean pulmonary to systemic arterial pressure ratio \<0.75 on most recent cardiac catheterization

• Stable PH medication regimen for 3 months prior to the intervention

• Home Wifi connection

• Mobile device in family capable of receiving text messages

Locations
United States
Pennsylvania
Children's Hospital of Philadelphia
RECRUITING
Philadelphia
Contact Information
Primary
Catherine Avitabile, MD
avitabilec@chop.edu
215-590-4040
Time Frame
Start Date: 2024-04-03
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 25
Treatments
Other: Home exercise intervention
* Personalized 16 week home exercise program - aerobic exercise for 20 minutes per day/4 days per week and light resistance exercise using resistance bands 3 days per week.~* Aerobic sessions will include walking, biking, or light jogging, depending on access to facilities/equipment and weather.~* Smartwatch for the length of the intervention and a heart rate monitor during exercise sessions.~* Max heart rate prescribed will be 80% of that on recent cardiopulmonary exercise test (at most 150 beats/min).~* Heart rate monitor will sync with the smartwatch.~* Activity and heart rate data will be transmitted to the study team via a data hub connected to the participant's home internet modem several times per week.~* Periodic text messaging to remind participants to wear the watch, sync the data, or adhere to heart rate goals, to ask about symptoms, or to support activity progress.~* Multiple ways to contact the study team with questions or concerns.
Related Therapeutic Areas
Sponsors
Leads: Children's Hospital of Philadelphia
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)

This content was sourced from clinicaltrials.gov