Development of IVF/ICSI Children Born From Frozen Embryo Transfer Cycles With Different Endometrial Preparation Protocols: Follow-up of a Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test, Other
Study Type: Observational
SUMMARY

The efficacy and safety of endometrial preparation regimens remain controversial. In the most recent meta-analysis, using natural and modified natural cycle protocol to prepare the endometrium in frozen embryo transfer resulted in higher live birth rates. In addition, the natural cycle reduces the risk of gestational hypertension, postpartum haemorrhage, and extremely preterm delivery compared with regimens using exogenous hormones. Because there are many physiological and endocrinal differences in the frozen embryo transfer cycle with different endometrial preparation protocols, the development of children born from these regimens has received much attention. For example, there is a complete absence of the corpus luteum during the cycle of exogenous hormone administration. Or in the modified natural cycle, the pharmacokinetics is not entirely the same as the natural physiology when using an additional ovulatory injection with hCG. To date, there have been no longitudinal follow-up studies that evaluated and compared the long-term development of IVF/ICSI children born from frozen embryo transfer with different endometrial preparation protocols. Thus, the investigators conduct a follow-up of our RCT to investigate the IVF/ICSI children born from frozen embryo transfer with different endometrial preparation protocols to give strong evidence about the safety of the three most common endometrial preparation protocols in women undergoing frozen embryo transfer.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 6 months
Maximum Age: 1
Healthy Volunteers: t
View:

• All live IVF/ICSI babies born from frozen embryo transfer following the natural cycle, modified natural cycle, and artificial cycle from MONART study

• Parents agree to participate in the study.

Locations
Other Locations
Viet Nam
My Duc Hospital
RECRUITING
Ho Chi Minh City
Contact Information
Primary
Hieu LT Hoang
bshieu.hlt@gmail.com
(+84) 969 166 318
Backup
Vu NA Ho
bsvu.hna@myduchospital.vn
(+84) 935 843 336
Time Frame
Start Date: 2022-08-12
Estimated Completion Date: 2025-12
Participants
Target number of participants: 700
Treatments
Natural cycle children
Children born from frozen embryo transfer with natural cycle protocol
Modified natural cycle children
Children born from frozen embryo transfer with modified natural cycle protocol
Artificial cycle children
Children born from frozen embryo transfer with artificial cycle protocol
Related Therapeutic Areas
Sponsors
Leads: Mỹ Đức Hospital

This content was sourced from clinicaltrials.gov

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