Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study

Status: Recruiting
Location: See location...
Intervention Type: Drug, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role of a specific salt sensing channel in the brain. Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will be given food to consume for 7-days. Comparisons will be made between salt resistant (no change in blood pressure going from low to high salt diets) and salt sensitive adults (a change in blood pressure going from low to high salt diets). The investigators think the changes in MRI will be greater in salt sensitive compared to salt resistant subjects.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 60
Healthy Volunteers: t
View:

• Age: \> 40 years or \< 60 years

• Blood pressure: \> 100/60 mmHg or \< 140/90 mmHg

• BMI: \> 18.5 kg/m2 or \< 30 kg/m2

• Serum potassium: \> 3.5 mmol/L or \< 5.5 mmol/L

• No history of cardiovascular, renal, metabolic, or neurological disease

Locations
United States
Delaware
University of Delaware
RECRUITING
Newark
Contact Information
Primary
Megan Wenner, PhD
mwenner@udel.edu
3028317343
Backup
Virginia Nuckols, PhD
gnuckols@udel.edu
Time Frame
Start Date: 2024-03-05
Estimated Completion Date: 2028-07
Participants
Target number of participants: 120
Treatments
Experimental: Salt Resistant Adults
Adults who experience minimal BP change during dietary sodium challenge
Experimental: Salt Sensitive
Adults who experience increased BP (mean arterial pressures \>5mmHg) during dietary sodium challenge
Related Therapeutic Areas
Sponsors
Leads: University of Delaware
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)

This content was sourced from clinicaltrials.gov

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